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pandora bracelets No one in the probiotic group and 9/53 (17%) in the placebo group had diarrhoea caused by C difficile (P=0.001). The absolute risk reduction was 17% (7% to 27%), and the number needed to treat was 6 (4 to 14).Conclusion Consumption of a probiotic drink containing L casei, L bulgaricus, and S thermophilus can reduce the incidence of antibiotic associated diarrhoea and C difficile associated diarrhoea. This has the potential to decrease morbidity, healthcare costs, and mortality if used routinely in patients aged over 50.Diarrhoea associated with antibiotic use and caused by Clostridium difficile is a complication of treatment with antimicrobial agents and occurs in about 5 25% of patients.3C difficile is responsible for around 15 25% of all cases of diarrhoea associated with antibiotic use, most occurring in older patients, usually in the two to three weeks after cessation of antibiotic treatment.4 Lactobacilli, bifidobacteria, and Streptococcus species have all been evaluated for the prevention or treatment of diarrhoea associated with antibiotic use and found to be safe.5 Several reviews support benefit but still call for large placebo controlled trials to determine species and dose effectiveness for prevention, to show effectiveness in preventing diarrhoea caused by C difficile, and to establish effect on length of hospital stay and cost effectiveness.6 7 8We undertook a randomised double blind, placebo controlled trial of a commercially available probiotic preparation in older patients in hospital who were receiving antibiotics.MethodsThe hypothesis was that a probiotic Lactobacillus preparation would reduce the incidence of antibiotic associated diarrhoea and C difficile associated diarrhoea pandora bracelets.